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Many cultures have historically recognized specific terpenes within cannabis and their potential benefits. The Declaration of Astana also acknowledges the need to draw on traditional knowledge and wisdoms in developing policies and practices to address health disparities.6 Not only are TCP-based practices derived from millennia of traditional knowledge but they are also community driven and community centered. There was no indication of a high RoB, however, because the participants were randomized using a computer-generated randomization schedule, fidelity to the intervention was addressed throughout the study, and missing data were identified and accounted for in analysis. Five of the studies targeted participants in either an inpatient or outpatient substance use treatment program, two studies targeted specific reservation communities, one study targeted inmates, one study targeted homeless individuals, and one study targeted college students. Finally, the cross-sectional studies were assessed for quality using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.25 This list contains 14 items evaluating quality criteria, and quality scores are assigned based on the number of criteria addressed adequately in the study. However, the historical record provides insufficient detail to ascertain whether the seventh century indications for cannabis in the context of wind-withdrawal overlapped with epilepsy or seizures, or whether the meaning was primarily limited to mental illness and/or erratic behavior.

The selected texts were organized chronologically by dynasty, and monographs on cannabis from bencao texts representing different historical periods were reviewed. Representative bencao texts were selected for analysis, including influential bencao texts from different dynastic periods, thematic bencao texts dedicated to specialized topics, and regional bencao texts dedicated to specific geographic regions (Zhao and Chen, 2014). Pre-modern Chinese materia medica texts, known as bencao, were systematically reviewed to investigate the historical applications of different parts of the cannabis plant. In more central Chinese regions, archeological artifacts provide abundant evidence of hemp fiber but little evidence of drug cannabis, suggesting that the historical divergence of fiber and drug biotypes occurred early in Chinese history (Clarke and Merlin, 2013). By contrast, many of the Chinese publications that have investigated historical questions related to the speciation of cannabis in Chinese medicine across different dynastic periods have adopted a polytypic approach to nomenclature that primarily differentiates the genus into two species based on chemotype, with varieties focused on fiber and seed production described as C. As the difference between drug and fiber varieties of cannabis is largely determined by genetics, the historical and geographic prevalence of different biotypes of cannabis in China likely influenced its applications in Chinese medicine.

Since prehistoric times, humans have used natural products, such as plants, animals, microorganisms, and marine organisms, in medicines to alleviate and treat diseases. Traditional African healing practices and the use of cannabis are deeply intertwined in many cultures across the continent, though the specifics vary greatly Permanent Marker strain profile depending on the region, community, and spiritual practices. Yoga and acupuncture are also examples of traditional healing practices that have been successfully used to address chronic health issues. For centuries across countries, people have turned to traditional healers, home remedies and ancient medicinal knowledge to address their health and well-being needs.

Indigenous Cultures’ Historical Usage of Cannabis

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Studies were included if they made reference to traditional medicine, or if they noted specific traditional medicine interventions or practitioners (i.e., sweat lodge, traditional healers, etc.). No limits were put on the type of research conducted, whether qualitative, quantitative, commentary, or otherwise given the specific nature of the topic and the assumed limited studies available for review. Considering the paucity of accessible information on traditional Indigenous medicine, in addition to the lack of cohesive understanding on what traditional healing is within the Western context, the purpose of this present study is– When Canadian Indigenous communities were asked about the challenges currently facing their communities, 82.6% stated that the most common issue was alcohol and drug abuse and that traditional medicine itself is a critically important part of Indigenous health , including in the support of addictions.

Hashish’s Emergence in the Middle East

In other words, herbs have become commonplace in American households and other developed countries to support a healthy, active lifestyle. Yet, very few of us are aware of the history and origins of the herbs we rely on today. It is crucial to respect and recognize the rights, customs, and practices of indigenous peoples in relation to cannabis and ensure that their voices are heard and their rights are protected.

Approval was granted for this study by the Institutional Review Board. A more holistic and patient-centered healthcare approach can be developed by merging ancient healing practices with contemporary medical science, thus addressing the physical, emotional, and spiritual needs of both individuals and communities. Nanoparticle-based drug delivery systems, for instance, are capable of specifically targeting cancer cells, which reduces side effects and enhances therapeutic results.

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What is the historical significance of Cannabis in traditional medicine?

With time, those natural products have undergone interesting and meaningful developments in their ability to interact with numerous, varied biological targets, and some have become the most important drugs in health care system 14,22,23. Considering their incomparable chemical diversity and novel mechanisms of action, natural products have continued to play a pivotal role in many drug development and research programs. That is especially true in the case of antihypertensives, where about 64% of newly-synthesized drugs have their origins in natural product structures . In that 22-year time frame, drugs derived from natural products have been significant. During the period between 1981 and 2002, the application of natural products in the development of new drugs—especially in the search for novel chemical structures—showed conspicuous success.

Cultural contexts and belief systems

Indigenous peoples often utilized marijuana to tackle issues related to digestive health. In addition, cannabis was utilized to treat various conditions including skin infections, joint inflammation, and inflammatory bowel diseases. The medicinal qualities of cannabis have been leveraged by traditional healers and shamans to relieve pain, decrease inflammation, and manage digestive issues.

For example, a researcher in 2003 found that plants used by curanderos (shamans) in the highlands of Mexico for the treatment of “sweet blood,” or diabetes, could be shown to successfully treat rats and humans with type 2 diabetes. A major belief of TCM is that illness results from the disruption or blockage of qi, or vital energy, which flows with blood through a network of twelve primary channels called “meridians.” Blockages are treated with acupuncture, acupressure, manipulative massage, or herbal medicines. The yin represents blood, spirit, and specific organs such as the heart, liver, and lungs, while the yang represents qi (pronounced “chee”) and organs such as the stomach, intestines, and bladder. The effectiveness of shamanic practices is difficult to study without impacting the cultures one is researching. In comparison with biomedical physicians who attempt to cure a disease, shamans strive to heal the condition. While some of these practices have been maintained only in small communities within their countries of origin, other practices remain in use as complementary and alternative healing practices in Western countries.

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In addition to cultural adherence, each study was evaluated for methodological quality using the RoB 2, ROBINS-I, or NIH checklist. For example, in their 2014 study, Dickerson et al.31 talk about how the processes of making drums and learning songs were adapted to meet the needs of a multi-tribal, urban community. The structure of the TCP measures varied broadly from a rigorous delivery schedule to cross-sectional surveys asking about participation in TCP during a specific period (e.g., last 12 months).

Conversely, countries like Canada and Uruguay have federally legalized both medical cannabis and recreational use. In some African countries like Nigeria and Egypt, cannabis use is illegal, and those caught in possession can face imprisonment or other punitive measures. In the Middle East, countries like Saudi Arabia and the United Arab Emirates have stringent anti-cannabis laws with severe punishments, including lengthy prison sentences and heavy fines. Several countries have implemented strict laws banning cannabis use and imposing severe penalties for its possession, cultivation, or distribution. Ancient Indians were likely familiar with different strains of cannabis, although specific cultivation practices and strain differentiation from that period are not extensively documented.

Due to the relatively recent introduction of TCPs into both clinical and academic research, a standardized language for literature reviews is currently lacking. The research team was made up of four individuals, including two American Indian researchers and two others with significant experience working with AIAN populations. Additionally, they pledged to support the establishment of policies and practices that integrate traditional knowledge and wisdom. Nevertheless, the available literature suggests that TCPs hold promise for effectively addressing problematic substance use in AIAN communities in a culturally aligned manner.

Natural products have a wide range of diversity of multi-dimensional chemical structures; in the meantime, the utility of natural products as biological function modifiers has also won considerable attention. Natural products will undergo continual use toward meeting the urgent need to develop effective drugs, and they will play a leading role in the discovery of drugs for treating human diseases, especially critical diseases . Over the past dozen years, increasing attention has accordingly been paid to natural products in the search for novel drugs in combination with new technology, such as high-throughput selection 13,14. Some large pharmaceutical companies are facing great challenges to develop new products. Some type of medicines, such as anticancer, antihypertensive, and antimigraine medication, have benefited greatly from natural products 10,12. However, natural products are important for the development of new drugs, and these products have been in constant use.

Turning to a more mystical perspective, cannabis also had an important role in spiritual practices. This article will explore the relaxed world of Native American cannabis usage, beginning with its historical origins that reach deep into the annals of time. The global use of cannabis by indigenous peoples showcases its cultural significance and versatility.